You are a superpower

Uncategorized Jul 15, 2020

It’s time to meet your Superheroes

There is cellular intelligence living within your DNA and genes

You don’t actually think about the blood flowing through your veins, nerve impulses, breathing, or digesting the breakfast you had this morning. If you workout in the morning, you don’t have to think about your muscles repairing themselves or bones becoming stronger. All of this just happens.

Take the skin for example. Let’s say you cut your finger – the wound healing process that goes on behind the scenes is an incredibly organized process. It starts with the immune system, removing all that damaged tissue. Then, the skin cells have to grow and divide in order to replace the damaged and missing tissue. Ultimately your finger becomes as good as new. It’s amazing because it all happens without you having to think about it.

This all happens because of the highly coordinated cellular intelligence your cells possess. But where does this intelligence live with your cells? It lives inside our DNA and genes.

Meet your superheroes

Every Breath you take
Nrf1 - Energy for you to fly
Nrf2 - A shield of defenses protecting your cells from damage
NAD - A sword to eliminate cell waste and toxins. Awaken your fighting spirit
Microbiome - Armor for your gut health and digestion...Your second brain

Cell signaling unlocks and coordinates cellular intelligence

When anything happens within your body, it’s due to a chain reaction. A signal is passed from the cell to the genes, and voila. Enzymes get to work. How that signal gets through the cell is an incredibly complex process, it’s always a chain reaction that we call coordinated cellular signaling which controls everything that happens within your cells and throughout your body and is what gives every cell in your body its cellular intelligence.

Nutrigenomics is the discovery that nutrients could activate health-promoting genes to take on one of life’s biggest mysteries…the normal aging process.

To help you live as healthy for as long as possible, it is important to understand the major theories of aging and most importantly how we use nutrigenomics to target them and activate your superheroes and super powers every day.

The Three Most Studied Theories of Aging

To date, there are currently three theories of aging that have been the most extensively studied:

The oxidative stress theory of aging - Nrf2
The mitochondrial theory of aging - Nrf1
The sirtuin theory of aging - NAD

While seemingly disjointed, all three of these theories of aging have a cellular signaling component. However, as we age, these signaling pathways both fail to react to their respective stimuli and stop working at their peak performance which is why we break down and problems of aging show up

Oxidative Stress Theory of Aging and Activating the Superhero Nrf2 Pathway

The oxidative stress theory of aging states that as we age we start to accumulate free radicals and other oxidants. If left unchecked, this oxidative stress can go on to have very serious consequences to the cell. Oxidative stress can ultimately lead to oxidative damage by attacking and damaging essential biological structures of the cell and ultimately compromises cellular function.

Antioxidants are the cell’s primary defense against free radicals and other oxidants. There are two major classes of antioxidants: 1) dietary antioxidants obtained through food and nutritional supplements and 2) endogenous antioxidants produced by the body.

It has long been debated which class of antioxidants is more important in human health. However, a recent review of the scientific literature led by the United States National Institutes of Health’s National Center for Complementary and Integrative Health concluded: “Rigorous trials of antioxidant supplements in large numbers of people have not found that high doses of antioxidant supplements prevent disease1.” Thus, much attention has shifted to the body’s endogenous antioxidant and detoxification systems.

Endogenous antioxidants are antioxidants made by the body and are the primary line of defense against oxidative stress. In general, endogenous antioxidants either prevent oxidants from being formed, or remove. Endogenous antioxidants form a complex network of antioxidant metabolites and enzymes. These networks work together, throughout the cell, to neutralize oxidants and protect important biological structures from oxidative damage.

However, with age, the activity of this Nrf2 cellular signaling pathway has been shown to decrease–both in its ability to sense oxidative threats and ultimately upregulate its target genes.

We all need a shield of defenses protecting our cells from damage. Meet Superhero Nrf2, the doctor and pharmacist in your cells, looking for problems and solving them.

"Nrf2 is both a monitor and a messenger, constantly on the lookout for problems with cells that may be caused by the many metabolic insults of life - oxidative stress, toxins, pollutants, and other metabolic dysfunction. When it finds a problem, Nrf2 essentially goes back to the cellular nucleus and rings the alarm bell, where it can "turn on" up to 200 genes that are responsible for cell repair, detoxification of carcinogens, protein and lipid metabolism, antioxidant protection and other actions. In their report, the scientists called it a "longevity-assurance" factor."

https://today.oregonstate.edu/archives/2015/dec/research-identifies-key-genetic-link-biology-aging

LifeVantage’s Protandim® Nrf2 Synergizer™ was specifically formulated to target the Nrf2 pathway. In a recent scientific study conducted by LifeVantage two health-promoting genes, NQO1 and HMOX1, known to be activated by Nrf2 were examined. What was found was that this formula was indeed able to activate these genes. It was shown that in just 24 hours there was a 40 percent increase in NQO1 and a 51 percent increase in HMOX1.*

What are the benefits of activating your superhero Nrf2?

A shield of defenses protecting your cells from damage
Supports the body’s natural detoxification processes*
Reduces oxidative stress by 40% in 30 days*
Significantly reduces cellular stress through Nrf2 activation*
Produces enzymes capable of neutralizing more than 1,000,000 free radicals*
Helps to regulate survival genes*
Supports the natural cellular repair and rejuvenation processes*

Mitochondrial Theory of Aging and the Activating the Superhero NRF1 Pathway

Another major theory of aging is the mitochondrial theory of aging. The mitochondria are essential for cellular function. It is estimated that about 95% of the energy we need to function every second of every day, is produced by the mitochondria. The mitochondria produce energy by breaking down the food we eat and capturing high-energy electrons in the process.

When mitochondria are functioning properly, they harness the energy of these electrons to produce energy for the cell. At the end of this process, the mitochondria attach these electrons to molecular oxygen that ultimately get detoxified to water. However, this process isn’t 100 percent efficient. Even in young, healthy mitochondria, electrons can escape this process potentially forming free radicals and other oxidants.

The mitochondrial theory of aging states that as we age, our mitochondria don’t work as efficiently. As the mitochondria age they don’t produce as much energy and also produce more free radicals and other oxidants. This mitochondrial damage goes on to further compromise mitochondrial function leading to a vicious downward spiral of even less mitochondrial efficiency and more free radical and oxidant production ultimately contributing to an increase in the overall cellular burden of oxidative stress.

There have been a number of nutrients shown to support mitochondrial health. These nutrients include alpha-lipoic acid, acetyl-L-carnitine, and coenzyme Q10. Alpha-lipoic acid is both fat- and water-soluble. It has 400 times the antioxidant power of vitamin E and C combined and shown to neutralize oxidants that damage mitochondria, can recycle other antioxidants, and regenerates glutathione. Acetyl-L-carnitine is an amino acid naturally produced in your body that helps generate energy. It is responsible for transporting fatty acids into the mitochondria where they are utilized for energy. Coenzyme Q10 is a fat-soluble antioxidant concentrated in the mitochondria. It is essential to shuttle electrons through the electron transport chain and ultimately in the production of ATP.

The NRF1 cellular signaling pathway, directly or indirectly, regulates a number of genes involved in mitochondrial health, turnover, biogenesis, and also healthy blood pressure and cholesterol levels.

LifeVantage’s Protandim® NRF1 Synergizer™ was specifically formulated to target the NRF1 pathway and provide nutrients shown to support mitochondrial health. In a recent scientific study conducted by LifeVantage two mitochondrial health-promoting genes, Nrf1 and PGC1-alpha, known to be activated by NRF1 were examined. What was found was that this formula was indeed able to activate these genes and in just 24 hours there was a 65 percent increase in NRF1 and a 71 percent increase in PGC1-alpha.*

What are the benefits for you in turning on the NRF1 pathway?

Energy to help you fly
Improves cellular performance through energy function*
Enhances cellular health*
Allows cells to function at peak performance*
Increases cellular energy (ATP)*

Sirtuin Theory of Aging and the NAD Pathway

Another major theory of aging is the sirtuin theory of aging. This theory came out of studies examining the health benefits of caloric restriction. Caloric restriction is the process whereby caloric intake is restricted by as much as 40 to 60 percent. In numerous experimental models, animals put on calorically restricted diets experienced significant increases in maximum lifespan by as much as 60 percent. It was ultimately determined that the family of proteins called the “sirtuins” were absolutely required to experience the increase in lifespan brought on by caloric restriction.

When the physiology of humans undergoing caloric restriction was examined, a number of health benefits were discovered. Humans undergoing caloric restriction experienced benefits in cardiovascular health, weight management, reproductive health, sleep, and cognitive function.

As researchers began to understand the molecular biology of these sirtuins, they found that the enzymatic activity for most of them required the molecule NAD+ (nicotinamide adenine dinucleotide). NAD+ is an essential molecule for many biochemical reactions, most notably metabolism of the food for energy. This is biologically important because an increase in NAD+ has been shown to activate several key enzymes, including sirtuin

LifeVantage’s Protandim® NAD Synergizer™ was specifically formulated to target the the most important genes in the NAD biosynthetic pathway, and has been shown to double sirtuin activity in 24 hours, supporting increased health, focus, energy, mental clarity, and mood. In a recent scientific study conducted by LifeVantage two NAD synthesizing genes were examined, NAMPT and NMNAT1. What was found was that this formula was indeed able to active these genes. It was shown that in just 24 hours there was a 12 percent increase in both of these genes. *

We were also curious about why the competition took the opposite approach. Instead of using nutrigenomics, other companies are trying to create sirtuin activity from scratch. Using this method, their products only show a 2 percent increase in sirtuin activity.

What are the benefits for you in activating the NAD pathway?

A sword to eliminate cell waste and toxins. Awaken your fighting spirit
Supports healthy longevity *
Supports autophagy (removal of cellular waste) *
Improves mental focus and concentration *
Supports positive mood and motivation *
Boosts mental and physical energy *
Supports body's healthy inflammatory response *
Maintain cholesterol levels already in the healthy range *
Supports healthy vascular system *

The Protandim family of products work synergistically to further activate these same genes*

After discovering how well the three products in the Protandim family were working individually, LifeVantage wanted to know if there was a cumulative, synergistic positive effect when all three products were given together.

The results exceeded our expectations:

Tri-Synergizer effect on Nrf2 Genes

When taken together, there was a 78 percent increase in the NQO1 gene responsible for fighting oxidative stress and detoxifying the body. There was also a 848 percent increase in HMOX1 for healthy inflammatory response. Together, these results show a further 83 percent and 1563 percent synergistic increase in NQO1 and HMOX1, respectively.*

Tri-Synergizer effect on NRF1 Genes

When taken together, there was a 90 percent increase in the Nrf1 gene responsible for overall cellular and mitochondrial health. There was also a 120 percent increase in PGC1-alpha–the gene responsible for mitochondrial turnover and biogenesis. Together, these results show a further 38 percent and 69 percent synergistic increase in Nrf1 and PGC1-alpha, respectively.*

Tri-Synergizer effect on NAD Genes

When taken together, there was a 128 percent increase in the NAMPT gene–a key enzyme in the NAD recycling pathway. There was also a 227 percent increase in NMNAT1 – the central enzyme for NAD synthesis. Together, these results show a further 967 percent and 1792 percent synergistic increase in NAMPT and NMNAT1, respectively.*

Nutrigenomics. A different approach to health with better results.

The true genius behind nutrigenomics lies, perhaps, in its untouched potential. The great news is that we’ve barely scratched the surface. The truly exciting news? Our products are just going to become exponentially better and more effective over the next decade.

Alone, Protandim NRF1, Nrf2, and now NAD Synergizers are each incredibly powerful, effective solutions. They’re helping our cells do some amazing things. But the magic we’re now seeing is the cumulative impact that happens when the entire Protandim family works together. The Tri-Synergizer isn’t just meeting our best-case scenarios in the lab – it’s far exceeding them. In the process, Tri-Synergizer is giving us a glimpse into both the incredible potential of Nutrigenomics, LifeVantage as a company, and what we can offer the world.*